期刊
SMALL
卷 7, 期 5, 页码 625-633出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201002291
关键词
-
类别
资金
- National Cancer Institute CCNE [U54 CA119367]
- In Vivo Cancer Molecular Imaging Centers ICMIC [P50 CA114747]
- Stanford Molecular Imaging Scholars Program SMIS [R25-T CA118681]
The affibody functionalization of fluorescent surface-enhanced Raman scattering gold-silica nanoparticles as multimodal contrast agents for molecular imaging specific to epidermal growth factor receptor (EGFR) is reported. This nanoparticle bioconjugate reports EGFR-positive A431 tumors with a signal nearly 35-fold higher than EGFR-negative MDA-435S tumors. The low-level EGFR expression in adjacent healthy tissue is 7-fold lower than in the positive tumors. Validation via competitive inhibition reduces the signal by a factor of six, and independent measurement of EGFR via flow cytometry correlates at R-2 = 0.92.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据