期刊
SMALL
卷 7, 期 14, 页码 2052-2060出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201100927
关键词
-
类别
资金
- 21C Frontier Functional Proteomics Project [FPR08-A2-150]
- Nano RD programme [2008-02890]
- National Research Foundation of Korea (NRF) from the Ministry of Education, Science and Technology [2009-0077361]
- Ministry of Knowledge Economy [10033183]
- BK21 program
- Seoul Science Fellowship
- Ministry of Health Welfare [0820320]
- KRIBB Research Initiative Program
- Korea Evaluation Institute of Industrial Technology (KEIT) [10033477] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [13-2008-00-015-00, 2009-0077361, 2011-0018198, 2007-0056335] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Radioactive iodine-labeled, cyclic RGD-PEGylated gold nanoparticle (AuNP) probes are designed and synthesized for targeting cancer cells and imaging tumor sites. These iodine-125-labeled cRGD-PEG-AuNP probes are stable in various conditions including a range of pHs and high salt and temperature conditions. These probes can target selectively and be taken up by tumor cells via integrin alpha(v)beta(3)-receptor-mediated endocytosis with no cytotoxicity. The probes show a significant increase in the avidity of alpha(v)beta(3) integrin compared to the corresponding free cRGD peptides. In-vivo SPECT/CT imaging results show that the iodine-125-labeled cRGD-PEG-AuNP probes can target the tumor site as soon as 10 min after injection, and also that cyclic RGD peptides are needed for efficient and long-term in-vivo monitoring. The results suggest that the probes circulate through the whole body, including renal filtration, and are excretable. These promising results show that radioactive-iodine-labeled gold nanoprobes have potential for highly specific and sensitive tumor imaging or for use as angiogenesis-targeted SPECT/CT imaging probes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据