期刊
SMALL
卷 6, 期 9, 页码 1044-1050出版社
WILEY-BLACKWELL
DOI: 10.1002/smll.200902384
关键词
biomimicry; gold nanoparticles; heparan sulfate; multivalency
类别
资金
- Elias, Genevieve and Geogianna Atol Charitable Trust
The use of modified nanoparticles in interactions with biological targets is attracting rapidly increasing attention. In this Full Paper, the application of gold nanoparticles capped with mercaptoethanesulfonate (Au-MES NPs) as effective inhibitors of Herpes simplex virus type 1 infection based on their ability to mimic cell-surface-receptor heparan sulfate is described. Mechanistic studies reveal that Au-MES NPs interfere with viral attachment, entry, and cell-to-cell spread, thereby preventing subsequent viral infection in a multimodal manner. The ligand multiplicity achieved with carrier nanoparticles is crucial in generating polyvalent interactions with the virus at high specificity, strength, and efficiency. Such multivalent-nanoparticle-mediated inhibition is a promising approach for alternative antiviral therapy.
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