期刊
SMALL
卷 6, 期 8, 页码 967-973出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200902132
关键词
biosensors; electrokinetics; field-effect transistors; nanotechnology; nanowires
类别
资金
- National Basic Research Program of China (973 Program) [2009CB930200]
- Special Presidential Foundation of Chinese Academy of Sciences [09312911ZX]
- Special National Natural Science Foundation of China [Y019111JJ]
High-sensitivity screening of biomarkers is critical to areas ranging from early disease detection and diagnosis to bioterrorism surveillance. Here the development of integrated nanoelectronic and electrokinetic devices for label-free attomolar detection of proteins is reported. Electrically addressable silicon nano wire field-effect transistors and electrodes for electrokinetic transport are integrated onto a common sensor chip platform, and the nano wire devices are subsequently functionalized with receptors for selective biomarker detection. Nano wire devices modified with monoclonal antibody for prostate specific antigen exhibit close to a 10(4) increase in sensitivity due to streaming dielectrophoresis and corresponding electrostatic contribution to the binding affinity after application of an AC electric field. The devices are also modified with receptors for cholera toxin subunit B and achieve a similar enhancement. These results show general applicability of this method, and could open up opportunities in early stage disease detection and the analysis of proteins from single cells.
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