期刊
SMALL
卷 6, 期 6, 页码 745-752出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200901557
关键词
cancer therapy; core/shell materials; gold sulfide; nanoparticles
类别
资金
- DOD CDMRP in Breast Cancer [DMI-0315965]
- NSF NSEC Center for Biological and Environmental Nanotechnology (CBEN) [EEC-0647452, NIH 5R01CA109385]
The development and optimization of near-infrared (NIR)-absorbing nano particles for use as photothermal cancer therapeutic agents has been ongoing. This work exploits the properties of gold/gold sulfide NIR-absorbing nanoparticles (approximate to 35-55 nm) that provide higher absorption (98% absorption and 2% scattering for gold/gold sulfide versus 70% absorption and 30% scattering for gold/silica nanoshells) as well as potentially better tumor penetration. The ability to ablate tumor cells in vitro and efficacy for photothermal cancer therapy is demonstrated, and an in vivo model shows significantly increased long-term, tumor-free survival. Furthermore, enhanced circulation and biodistribution is observed in vivo. This class of NIR-absorbing nanoparticles has the potential to improve upon photothermal tumor ablation for cancer therapy.
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