期刊
SMALL
卷 6, 期 22, 页码 2546-2552出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201000841
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资金
- National Cancer Institute of the National Institutes of Health [U54 CA 119335, 5-R01-CA124427, U54 CA119349]
- National Science Foundation [DMR-0806859]
- Korea Science and Engineering Foundation (KOSEF)
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0806859] Funding Source: National Science Foundation
Magnetic manipulation, fluorescent tracking, and localized delivery of a drug payload to cancer cells in vitro is demonstrated, using nanostructured porous silicon microparticles as a carrier. The multifunctional microparticles are prepared by electrochemical porosification of a silicon wafer in a hydrofluoric acid-containing electrolyte, followed by removal and fracture of the porous layer into particles using ultrasound. The intrinsically luminescent particles are loaded with sttperparamagnetic iron oxide nanoparticles and the anti-cancer drug doxorubicin. The drug-containing particles are delivered to human cervical cancer (HeLa) cells in vitro, under the guidance of a magnetic field. The high concentration of particles in the proximity of the magnetic field results in a high concentration of drug being released in that region of the Petri dish, and localized cell death is confirmed by cellular viability assay (Calcein AM).
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