期刊
SMALL
卷 5, 期 5, 页码 544-557出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200801079
关键词
atherosclerosis; hybrid materials; molecular imaging; nanoparticles; optical imaging
类别
资金
- SenterNovem
- BSIK [03033]
Molecular imaging contributes to furture personalized medicine dedicated to the treatment of cardiovascular disease, the leading cause of mortality in industrialized countries. Endoscope-compatible optical imaging techniques would offer a stand-alone alternative and high spatial resolution validation technique to clinically accepted imaging techniques in the (intravascular) assessment of vulnerable atherosclerotic lesions, which are predisposed to initiate acute clinical events. Efficient optical visualization of molecular epitopes specific for vulnerable atherosclerotic lesions requires targeting of high-qulaity optical-contrast-enhancing particles. In this review, we provide an overview of both current optical nanoparticles and targeting ligands for optical molecular imaging of atherosclerotic lesions and speculate on their applicability in the clinical setting.
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