期刊
SMALL
卷 5, 期 13, 页码 1562-1568出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200900186
关键词
antibodies; biomolecules; nanoparticles; polymers; protein recognition
类别
资金
- National Institutes of Health [GM 080506]
Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.
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