期刊
SMALL
卷 5, 期 17, 页码 1990-1996出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200900520
关键词
cellular uptake; F3 peptide; iron oxide nanoparticles; Zeta potential
类别
资金
- National Cancer Institute (NCI)
Surface-charge measurements of mammalian cells in terms of Zeta potential are demonstrated as a useful biological characteristic in identifying cellular interactions with specific nanomaterials. A theoretical model of the changes in Zeta potential of cells after incubation with nanoparticles is established to predict the possible patterns of Zeta-potential change to reveal the binding and internalization effects. The experimental results show a distinct Pattern of Zeta potential change that allows the discrimination of human normal breast epithelial cells (MCF-10A) from human cancer breast epithelial cells (MCF-7) when the cells are incubated with dextran coated iron oxide nanoparticles that contain tumor-homing F3 peptides, where the tumor-homing F3 peptide specifically bound to nucleolin receptors that are overexpressed in cancer breast cells.
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