期刊
SMALL
卷 4, 期 11, 页码 2025-2034出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200800199
关键词
cytotoxicity; magnetic nanopartictes; reactive oxygen species; silica
类别
资金
- Spanish Nonoscience Action [Spanish Nonoscience Action NAN200409270-C3-1/2]
- Consolider Ingenio 2010 program [CSD2006-00012]
- Xunta de Galicia, Spain [PGI-D1T06TMT31402PR]
- [order ECI/158/2005]
Inorganic nanoparticles (NPs) show great potential for medicinal therapy. However, biocompatibility studies are essential to determine if they are safe. Here, five different NPs are compared for their cytotoxicity, internalization, aggregation in medium, and reactive oxygen species (ROS) production, using tumoral and normal human blood cells. Differences depending on the cell type are analyzed, and no direct correlation between ROS production and cell toxicity is found. Results are discussed with the aim of standardizing the procedures for the evaluation of the toxicity.
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