期刊
SMALL
卷 4, 期 5, 页码 634-641出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200700308
关键词
cells; fluid dynamics; hydrophoresis; microfluidics; microparticles
类别
资金
- National Research Foundation of Korea [2005-01291, 핵06A3602] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This paper presents a microfluidic device for sheathless focusing of microbeads and blood cells based on a hydrophoretic platform comprising a V-shaped obstacle array (VOA). The VOA generates lateral pressure gradients that induce helical recirculations. Following the focusing flow particles passing through the VOA are focused in the center of the channel. In the device, the focusing pattern can be modulated by varying the gap height of the VOA. To achieve complete focusing within 4.4% coefficient of variation, the relative size differences between the gap and the particle were 3 and 4 mu m for 10 and 15 mu m beads, respectively. Red blood cells were used to study the hydrophoretic focusing pattern of biconcave, disk-shaped particles.
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