期刊
SMALL
卷 4, 期 9, 页码 1437-1444出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200701285
关键词
atherosclerosis; biomimetics; cell recognition; imaging; nanopartictes
类别
资金
- NIH National Cancer Institute [5R24 CA095823-04]
- National Science Foundation [DBI-9724504]
- NIH [1 S10 RRo 9145-01]
- NIH/NHLBI [ROI HL71021, HL78667]
Cardiovascular disease is one of the prime causes of mortality throughout the world and there is a need for targeted and effective contrast agents to allow noninvasive imaging of the cholesterol-rich atherosclerotic plaques in arteries. A new, fully synthetic, high-density lipoprotein (HDL)-mimicking MRI contrast agent is developed, which enhances macrophage-rich areas of plaque in a mouse model of atherosclerosis by 94%. Confirmation of the targeting of this nanoparticulate agent is achieved using confocal microscopy by tracking a fluorescent lipid incorporated into the nanoparticle.
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