期刊
SLEEP MEDICINE
卷 9, 期 4, 页码 343-351出版社
ELSEVIER
DOI: 10.1016/j.sleep.2007.06.013
关键词
idiopathic REM sleep behaviour disorder; early markers; neuropsychological performances; Lewy body disease; Parkinson's disease
Background: Rapid eye movement [REM] sleep behaviour disorder (RBD) may herald neurodegenerative diseases. Neurobiological deficits similar to those identified in neurodegenerative diseases have been reported in idiopathic RBD. Researchers are looking for early markers supporting a possible role of RBD as a harbinger of impending neurodegenerative disease. Objective: To examine the neuropsychological functions in idiopathic RBD subjects. Should they be found to present a neuropsychological dysfunction that overlaps that reported in neurodegenerative diseases, it would be possible to consider cognitive deficits as possible early markers of an underlying degenerative process. Methods: Twenty-three subjects with idiopathic RBD (21 males, mean age 67.0 +/- 7.0 years) and a group of healthy controls matched for sex, age and education underwent a neuropsychological battery evaluating different cognitive domains. Findings: Considering mean values, poorer performances were observed in the Word Span (p <.001), Rey-Osterrieth's complex figure recall (p =.003), Digit Span (p =.003) and Logic Memory (p =.003) tests. On the basis of equivalent scores, the RBD subjects performed significantly more poorly on tests of visuo-constructional learning abilities (p <.001). Interpretation: Our data show the possible presence of cognitive deficits in RBD defined as idiopathic, sharing common features in particular with Lewy body disease. Neuropsychological evaluation in RBD could lead to presymptomatic identification of neurodegenerative disease, but until more prolonged long-term follow-up data are available, the true neurobiological significance of cognitive deficits in RBD will remain unknown. (C) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据