期刊
SLEEP MEDICINE
卷 9, 期 4, 页码 393-402出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.sleep.2007.06.006
关键词
gaboxadol; slow wave sleep; transient insomnia; selective extrasynaptic GABA agonist; phase-advance; SEGA; sleep maintenance; sleep onset
Objective: The hypnotic efficacy of gaboxadol, a selective extrasynaptic GABA(A) agonist (SEGA), was evaluated in a phase-advance model of transient insomnia. Methods: Healthy subjects (18-64 years) completed a randomized, double-blind, parallel group study in which the sleep period was advanced 4 h from habitual sleep time. Polysomnographic (PSG) and self-reported sleep measures were used to compare gaboxadol 10 mg (N = 271) and 15 mg (N = 274) versus placebo (N = 277). Results: In the placebo group, the phase-advance procedure disrupted sleep maintenance as measured by PSG wakefulness after sleep onset (WASO) and self-reported WASO (sWASO), and also, to a lesser extent, disrupted sleep onset as measured by PSG latency to persistent sleep (LPS) and self-reported time to sleep onset (sTSO). Both doses of gaboxadol decreased WASO and sWASO versus placebo (p <= 0.05). Gaboxaclol 15 mg also reduced LPS versus placebo (p <= 0.01) and both doses reduced sTSO versus placebo (p <= 0.01). PSG and self-reported total sleep time as well as ratings of sleep quality were improved with both gaboxadol doses relative to placebo (all p <= 0.01 or better). The amount of slow wave sleep (SWS) was greater with both doses of gaboxadol than with placebo (p) <= 0.001). No group differences in the amount of rapid eye movement sleep were found. Most PSG and self-report measures indicated a mild dose response. The percentage of subjects with adverse events was low (<10% in any treatment group) and all were mild or moderate; none were serious and gaboxadol did not impact morning gait or coordination. Conclusions: Gaboxadol 10 and 15 mg were efficacious insignificantly reducing the sleep maintenance and sleep onset disruption produced by this model of transient insomnia, with effects generally being most pronounced for the 15 mg dose. Gaboxadol also enhanced SWS. (C) 2007 Elsevier B.V. All rights reserved.
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