期刊
SLEEP
卷 36, 期 6, 页码 841-847出版社
OXFORD UNIV PRESS INC
DOI: 10.5665/sleep.2708
关键词
Obesity; obstructive sleep apnea syndrome; adenotonsillectomy
资金
- National Institutes of Health [HD-053693]
Objective: The reasons why adenotonsillectomy (AT) is less effective treating obese children with obstructive sleep apnea syndrome (OSAS) are not understood. Thus, the aim of the study was to evaluate how anatomical factors contributing to airway obstruction are affected by AT in these children. Methods: Twenty-seven obese children with OSAS (age 13.0 +/- 2.3 y, body mass index Z-score 2.5 +/- 0.3) underwent polysomnography and magnetic resonance imaging of the head during wakefulness before and after AT. Volumetric analysis of the upper airway and surrounding tissues was performed using commercial software (AMIRA (R)). Results: Patients were followed for 6.1 +/- 3.6 mo after AT. AT improved mean obstructive apnea-hypopnea index (AHI) from 23.7 +/- 21.4 to 5.6 +/- 8.7 (P < 0.001). Resolution of OSAS was noted in 44% (12 of 27), but only in 22% (4 of 18) of those with severe OSAS (AHI > 10). AT increased the volume of the nasopharynx and oropharynx (2.9 +/- 1.3 versus 4.4 +/- 0.9 cm(3), P < 0.001, and 3.2 +/- 1.2 versus 4.3 +/- 2.0 cm(3), P < 0.01, respectively), reduced tonsils (11.3 +/- 4.3 versus 1.3 +/- 1.4 cm(3), P < 0.001), but had no effect on the adenoid, lingual tonsil, or retropharyngeal nodes. A small significant increase in the volume of the soft palate and tongue was also noted (7.3 +/- 2.5 versus 8.0 +/- 1.9 cm(3), P = 0.02, and 88.2 +/- 18.3 versus 89.3 +/- 24.4 cm(3), P = 0.005, respectively). Conclusions: This is the first report to quantify volumetric changes in the upper airway in obese children with OSAS after adenotonsillectomy showing significant residual adenoid tissue and an increase in the volume of the tongue and soft palate. These findings could explain the low success rate of AT reported in obese children with OSAS and are important considerations for clinicians treating these children.
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