期刊
SLEEP
卷 34, 期 3, 页码 303-U207出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/34.3.303
关键词
Obstructive sleep apnea; neurocognition; epidemiology; sleep; oxygen desaturation
资金
- Pfizer
- Merck
- Somaxon
- Evotec
- Actelion
- Vanda
- Neurogen
- Sanofi-Aventis
- Ventus Medical
- Respironics
- Jazz
- Cephalon
- Pacific Medico
- GlaxoSmithKline
- Xenoport
Study Objectives: To determine associations between obstructive sleep apnea (OSA) and neurocognitive performance in a large cohort of adults. Study Design: Cross-sectional analyses of polysomnographic and neurocognitive data from 1204 adult participants with a clinical diagnosis of obstructive sleep apnea (OSA) in the Apnea Positive Pressure Long-term Efficacy Study (APPLES), assessed at baseline before randomization to either continuous positive airway pressure (CPAP) or sham CPAP. Measurements: Sleep and respiratory indices obtained by laboratory polysomnography and several measures of neurocognitive performance. Results: Weak correlations were found for both the apnea hypopnea index (AHI) and several indices of oxygen desaturation and neurocognitive performance in unadjusted analyses. After adjustment for level of education, ethnicity, and gender, there was no association between the AHI and neurocognitive performance. However, severity of oxygen desaturation was weakly associated with worse neurocognitive performance on some measures of intelligence, attention, and processing speed. Conclusions: The impact of OSA on neurocognitive performance is small for many individuals with this condition and is most related to the severity of hypoxemia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据