期刊
SLEEP
卷 34, 期 9, 页码 1215-1219出版社
OXFORD UNIV PRESS INC
DOI: 10.5665/SLEEP.1242
关键词
Circadian rhythm; cataract; melanopsin; sleep
资金
- Danish Medical Research Council
- Danish Centre for Evaluation and Health Technology Assessment
- Novo Nordisk, Copenhagen County
- Danish Heart Foundation,
- Danish Pharmaceutical Association, Augustinus foundation
- Ib Henriksen foundation and Becket foundation
- Danish Diabetes Association
- Danish Organisation for Prevention of Vision
- Danish Association of the Blind (Ojenfonden), and through Juvenile Diabetes Research Foundation [8-2002-130]
Study Objectives: Sleep pattern and circadian rhythms are regulated via the retinohypothalamic tract in response to stimulation of a subset of retinal ganglion cells, predominantly by blue light (450-490 nm). With age, the transmission of blue light to the retina is reduced because of the aging process of the human lens, and this may impair the photoentrainment of circadian rhythm leading to sleep disorders. The aims of the study was to examine the association between lens aging and sleep disorders. Design: Cross-sectional population based study. Setting: The study was performed at the Research Center for Prevention and Health, Glosrup Hospital, Denmark and at the Department of Ophthalmology, Herlev Hospital, Denmark. Participants: An age- and sex-stratified sample of 970 persons aged 30 to 60 years of age drawn from a sample randomly selected from the background population. Interventions: Not applicable. Measurements and Results: Sleep disurbances were evaluated by a combination of questionnaire and the use of prescription sleeping medical-increased whtn the transmission of blue light to the retina was low, even after correction for the effect of age and other confounding factors such as smoking habits, diabetes mellitus, gender, and the risk of ischemic heart disease (P < 0.0001). Conclusions: Filtration of blue light by the aging lens was significantly associated with an increased risk of sleep disturbances. We propose that this is a result of disturbance of photoentrainment of circadian rhythms.
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