期刊
SLEEP
卷 31, 期 5, 页码 717-723出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/31.5.717
关键词
REM sleep behavior disorder (RBD); Parkinson disease (PD); synucleinopathies; Lewy body disease (LBD); cardiac I-123-MIBG scintigraphy
Objective: RBD is considered to be a manifestation of an evolving synucleinopathy, such as Parkinson disease (PD), dementia of Lewy bodies (DLB), and multiple system atrophy (MSA). We tested whether the degree of accumulation of cardiac I-123-MIBG scintigraphy can distinguish the clinical syndromes associated with Lewy body-related disease from the syndrome of PSP (a tauopathy) and MSA. Design: Cross-sectional. Setting: University-based sleep disorders laboratory. Patients: Subjects comprised 95 patients (31, idiopathic RBD; 26, PD; 10, MSA; 6, DLB; 13, progressive supranuclear palsy [PSP]) and 9 control subjects. Intervention: To compare tracer uptake of cardiac I-123-MIBG between idiopathic RBD, PD, MSA, DLB, and PSP and control subjects. Measurements and Results: Cardiac I-123-MIBG accumulation was evaluated by the heart/mediastinum (H/M) ratio. Mean value of the H/M ratio (early, delayed) was significantly reduced in patients with idiopathic RBD compared to MSA patients, PSP patients, control subjects (P < 0.001 in each group) and PD patients in early images (P < 0.05). There was a correlation between the H/M ratio and disease duration in the idiopathic RBD group. ROC analysis revealed that an H/M cut-off value of 1.9 was useful for differentiating RBD from MSA and PSP as well as distinguishing control subjects from those with RBD in both early and delayed images. Conclusion: Cardiac I-123-MIBG findings are similar among idiopathic RBD and the syndromes of PD and DLB, but differ from those of PSP and MSA.
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