Associations of usual sleep duration with serum lipid and lipoprotein levels

Study Objectives: We examined the individual association between sleep duration and a high serum triglyceride, low HDL cholesterol, or high LDL cholesterol level. Design and Setting: The present study analyzed data from the National Health and Nutrition Survey that was conducted in November 2003 by the Japanese Ministry of Health, Labour and Welfare. This survey was conducted on residents in the districts selected randomly from all over Japan. Participants: The subjects included in the statistical analysis were 1,666 men and 2,329 women aged 20 years or older. Intervention: N/A Measurements and Results: Among women, both short and long sleep durations are associated with a high serum triglyceride level or a low HDL cholesterol level. Compared with women sleeping 6 to 7 h, the relative risk of a high triglyceride level among women sleeping < 5 h was 1.51 (95% Cl, 0.96-2.35), and among women sleeping >= 8 h was 1.45 (95% Cl, 1.00-2.11); the relative risk of a low HDL cholesterol level among women sleeping < 5 h was 5.85 (95% Cl, 2.29-14.94), and among women sleeping >= 8 h was 4.27 (95% Cl, 1,88-9.72). On the other hand, it was observed that the risk of a high LDL cholesterol level was lower among men sleeping >= 8 h. These analyses were adjusted for the following items: age, blood pressure, body mass index, plasma glucose level, smoking habit, alcohol consumption, dietary habits, psychological stress, and taking cholesterol-lowering medications. Conclusions: Usual sleep duration is closely associated with serum lipid and lipoprotein levels.