期刊
SKIN PHARMACOLOGY AND PHYSIOLOGY
卷 22, 期 3, 页码 128-130出版社
KARGER
DOI: 10.1159/000189801
关键词
Vehicle effects; Skin hydration; Stratum corneum; Transepidermal water loss; Microemulsion; Transcutol
The stratum corneum, the outermost layer of the skin, regulates the passive loss of water to the environment. Furthermore, it is well accepted that drug penetration is influenced by skin hydration, which may be manipulated by the application of moisturizing or oleaginous vehicles. Measurements of transepidermal water loss (TEWL), and of skin hydration using a corneometer, were used to assess the effect of different vehicles on stratum corneum barrier function in vivo in human volunteers. A microemulsion significantly increased skin hydration relative to a reference vehicle based on medium chain triglycerides; in contrast, Transcutol (R) lowered skin hydration. TEWL measurements confirmed these observations. Copyright (C) 2009 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据