期刊
SOCIAL SCIENCE & MEDICINE
卷 127, 期 -, 页码 171-180出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.socscimed.2014.08.001
关键词
Education; Health; Depression; Self-rated health; BMI; Genetics
资金
- National Institutes of Aging [U01 AG009740]
- Social Security Administration
- Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHE) [R21 HD078031, R01 HD060726]
- NIH/NICHD - University of Colorado Population Center [R24 HD066613]
We use genome wide data from respondents of the Health and Retirement Study (HRS) to evaluate the possibility that common genetic influences are associated with education and three health outcomes: depression, self-rated health, and body mass index. We use a total of 1.7 million single nucleotide polymorphisms obtained from the Illumina HumanOmni2.5-4v1 chip from 4233 non-Hispanic white respondents to characterize genetic similarities among unrelated persons in the HRS. We then used the Genome Wide Complex Trait Analysis (GCTA) toolkit, to estimate univariate and bivariate heritability. We provide evidence that education (h(2) = 0.33), BMI (h(2) = 0.43), depression (h(2) = 0.19), and self-rated health (h(2) = 0.18) are all moderately heritable phenotypes. We also provide evidence that some of the correlation between depression and education as well as self-rated health and education is due to common genetic factors associated with one or both traits. We find no evidence that the correlation between education and BMI is influenced by common genetic factors. (C) 2014 Elsevier Ltd. All rights reserved.
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