期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep11252
关键词
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资金
- University Medical School of Catania
- Alzheimer's Association [IIRG-09-134220]
- University of Catania
- IRCCS Oasi Maria SS. Troina [RC-02-01, RC-06-08]
Transforming Growth Factor beta 1 (TGF-beta 1) is a well-known neuroprotective and neurotrophic factor demonstrated to play a role in synaptic transmission. However, its involvement in physiological mechanisms underlying synaptic plasticity and memory at hippocampal level has not been thoroughly investigated. Here, we examine the role of TGF-beta 1 in hippocampal long-term potentiation (LTP) and memory in adult wild type mice. Our data provide evidence that administration of exogenous TGF-beta 1 is able to convert early-phase-LTP into late-phase-LTP. Furthermore, we show that the block of the endogenous TGF-beta 1 signaling pathway by the specific TGF-beta 1 inhibitor SB431542, impairs LTP and object recognition memory. The latter impairment was rescued by administration of exogenous TGF-beta 1, suggesting that endogenously produced TGF-beta 1 plays a role in physiological mechanisms underlying LTP and memory. Finally, TGF-beta 1 functional effect correlates with an increased expression of the phosphorylated transcription factor cAMP-Responsive Element Binding protein.
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