期刊
SEPARATION AND PURIFICATION TECHNOLOGY
卷 69, 期 3, 页码 269-274出版社
ELSEVIER
DOI: 10.1016/j.seppur.2009.08.002
关键词
Protein enrichment; Forward osmosis; Dual-layer hollow fiber membrane; Nanofiltration; Polybenzimidazole; Dewater
资金
- National University of Singapore
- National Research Foundation, Singapore [R-279-000-249-646, R-279-000-271-272]
We have demonstrated the prospect of dual-layer polybenzimidazole-polyethersulfone/polyvinylpyrrolidone (PBI-PES/PVP) hollow fiber nanofiltration (NF) membranes in the forward osmosis (FO) process for the enrichment and concentration of pharmaceutical products without denaturing the component of interests. The dual-layer hollow fiber membrane via coextrusion technology has an ultra-thin selective skin around 10 mu m, fully open-cell water channels underneath and a microporous spongelike support structure. The self-charged PBI selective skin has an average pore radius at 0.4 nm with a sharp pore size distribution. Experimental results show that the newly developed dual-layer hollow fiber nanofiltration membrane can achieve a high throughput for lysozyme enrichment and less protein fouling when using it as a FO membrane. In addition, the high divalent salt rejection towards Mg2+ at around 90% of this dual-layer membrane ensures the enriched lysozyme product with high purity and without change and denaturing. (C) 2009 Elsevier B.V. All rights reserved.
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