期刊
SEPARATION AND PURIFICATION REVIEWS
卷 44, 期 2, 页码 157-182出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15422119.2014.918884
关键词
Organic solvent nanofiltration; solvent resistant nanofiltration; active pharmaceutical ingredients (APIs); solvent exchange; product purification; genotoxin impurities (GTIs); membrane enhanced peptide synthesis (MEPS); hybrid processes
Organic solvent nanofiltration (OSN) is a promising energy and waste efficient unit process to separate mixtures down to a molecular level, which gained attention in the pharmaceutical industry, in particular in the process development of Active Pharmaceutical Ingredients (APIs). This article focuses on all aspects related to OSN (i.e., membrane materials, commercial membranes, transport theories, applications) to understand the role of this technology in pharmaceutical industry. The most important results in the last five years on OSN applications in the process development of APIs are reviewed extensively.
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