期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep14692
关键词
-
资金
- National Institutes of Health [AI-078277, CA-127099]
- Spanish Ministry of Economy Plan Nacional [SAF2012-34610, BFU2011-25986]
- Basque Government Dept. of Industry, Tourism and Trade (Etortek)
- Basque Government Dept. of Health [2012111086]
- Basque Government Dept. of Education [PI2012-03, PI2012/42]
- Instituto de Salud Carlos III [PI10/01484, PI13/00031]
- Marie Curie [277043]
- ERC [336343]
- Ramon y Cajal Award
- Spanish Association Against Cancer (AECC)
- European Research Council (ERC) [336343] Funding Source: European Research Council (ERC)
MCJ (DNAJC15) is a mitochondrial protein that regulates the mitochondrial metabolic status of macrophages and their response to inflammatory stimuli. CpG island methylation in cancer cells constitutes the only mechanism identified for the regulation of MCJ gene expression. However, whether DNA methylation or transcriptional regulation mechanisms are involved in the physiological control of this gene expression in non-tumor cells remains unknown. We now demonstrate a mechanism of regulation of MCJ expression that is independent of DNA methylation. IFN gamma, a protective cytokine against cardiac inflammation during Lyme borreliosis, represses MCJ transcription in macrophages. The transcriptional regulator, Ikaros, binds to the MCJ promoter in a Casein kinase II-dependent manner, and mediates the repression of MCJ expression. These results identify the MCJ gene as a transcriptional target of IFN gamma and provide evidence of the dynamic adaptation of normal tissues to changes in the environment as a way to adapt metabolically to new conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据