期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 277, 期 -, 页码 502-509出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.09.044
关键词
Lateral flow assay; Core-shell SERS nanotags; multiplex detection; Acute myocardial infarction
资金
- National Key Research and Development Program of China [2018YFF0215200, 2017YFA0205700]
- National Natural Science Foundation of China [21373046, 21327902, 61850410528]
- Natural Science Foundation of Jiangsu Province [BK2014021828, BE2016002]
- Fundamental Research Funds for the Central Universities
- Six Talent Peaks Project of Jiangsu Province
- Collaboration Research Fund of Southeast University
- Nanjing Medical University [2242017K3DN26]
- Fundamental Research Project of Shenzhen Science & Technology Innovation Committee [201803063001075]
- Key Laboratory of Environmental Medicine Engineering of Ministry of Education
Quick and accurate quantification of multiple biomarkers is quite a challenge in high throughput detection. Herein, we developed a novel lateral flow assay (LFA) based on Raman dyes (RDs) encoded core-shell surface enhanced Raman scattering (SERS) nanotags for rapid quantification of three cardiac biomarkers on a single test (T) line for early diagnosis of acute myocardial infarction (AMI). Owing to the signal amplification of encoded SERS nanotags and high surface area to volume ratio (SVR) of nitrocellulose (NC) membrane, rapid quantification of CK-MB, cTnI, and Myo with ultra-high sensitivity and wide linear dynamic range (LDR) was realized. We envision this method to find wide applications in in vitro diagnostics (IVD).
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