期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 277, 期 -, 页码 408-414出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.09.054
关键词
Heparin; Protamine; AIE sensor; Electrostatic interaction
资金
- National Key R&D program of China [2017YFD0200302]
- NSFC [21604085, 21702127, 21802166]
- Jilin Science Foundation for Youths [20160520135JH]
- Fundamental Research Funds for the Central Universities [ZY1831]
- State Key Laboratory of Molecular Engineering of Polymers, Fudan University [K2018-26]
- State Key Laboratory of Polymer Physics and Chemistry, CIAC
In this research a four-armed amino-tailored tetraphenylethene TPE-NH2 was synthesized, and it could detect heparin (Hep) quantitatively, primarily promoted by the electrostatic interactions between its positively charged amino groups and the sulfates, carboxylates of heparin. On account of the aggregation-induced emission (AIE) nature of tetraphenylethene backbone, the aggregation restricted the rotation of CeC single bond through rigidifying the conformation of TPE-NH2, thus making it display intense fluorescence with a broad working range (<= 2.0 mu g/mL) and a low detection limit (down to 35.89 ng/mL) for heparin. Meanwhile, the TPE-NH2/Hep complex can be further disaggregated by protamine due to the stronger affinity between heparin and protamine, consequently leading to the highly sensitive detection of protamine. What's more, the low toxicity of TPE-NH2 makes it a potential functional sensor for detecting heparin in the matrix of human serum.
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