期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 203, 期 -, 页码 683-689出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2014.06.043
关键词
Dual functional lateral flow sensor; Fluorescent quenching; Clenbuterol; Small molecule analyte
资金
- Scientific Research Foundation of Chinese Ministry of Education [47]
- Technology Research Program of Guangdong Province [2011B020314005]
Recently, more sensitive methods for analyzing small molecule analytes were required. Lateral-flow sensors (LFSs) have been used as reliable, rapid and cost-effective on-site screening technique to detect small molecule analytes. However, available LFSs for small molecule analytes were competitive and performed in turn-off mode, allowing low-sensitivity detection by the naked eye. In this study, we used dual-functional LFSs for monitoring small molecule analytes (clenbuterol CL), which based a fluorescence-quenching effect of gold nanoparticles (AuNPs). The most important feature of this sensor is its dual function as turn-on LFSs under excitation light and turn-off LFSs under natural light. The sensitivity of turn-on LFSs reached 0.04 ng/m under excitation light; however, under natural light they performed as common turn-off AuNPs LFSs with 5.0 ng/mL sensitivity. This novel LFS can be used in either traditional or highly sensitive tools to detect a variety of small analytes. (C) 2014 Elsevier B.V. All rights reserved.
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