期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 203, 期 -, 页码 388-395出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2014.07.007
关键词
Non-enzymatic sensor; Glucose; Nanoporous gold film; Cu coating; Electron mediator; Co-mediating
资金
- National Natural Science Foundation of China [21003045, 21173075]
- Ph.D. Programs Foundation of the Ministry of Education of the People's Republic of China [20104306110003]
- Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
- Construct Program of the Key Discipline in Hunan Province
In this work, we constructed an ultrasensitive non-enzymatic amperometric glucose sensor based on a Cu-coated nanoporous gold film (Cu/NPGF) for the first time, which comprised two pairs of electron mediators, Cu(II)/Cu(III) and Au/Au(I). The nanoporous gold film with high roughness (R=136) was prepared by anodic potential step and the very thin Cu coating into/on the nanoporous Au was electrodeposited at constant current. In comparison with electrodeposited Cu on a smooth gold surface and with the nanoporous Au, the prepared Cu/NPGF showed significantly enhanced electrocatalytic activity for the oxidation of glucose around 0.1 V due to its nanoporous structure and the pronounced co-mediating of Cu(II)/Cu(III) and Au/Au(I), as well as their coupling Cu(III) + Au = Cu(II)+Au(I). The Cu functionalized NPGF electrode also exhibited an extraordinary performance in sensing glucose with a wide linear range (2 mu M-8.11 mM), short response time (3 s), ultrasensitivity (3643 mu AmM-1 cm(-2)), low detection limit (0.59 mu M), good anti-interference and anti-toxicity, long-term stability (over 3 weeks), and satisfactory quantification of glucose concentration in human serum. We expect that functionalization of nanoporous gold films will provide a new platform for electrochemical sensors. (C) 2014 Elsevier B.V. All rights reserved.
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