期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 178, 期 -, 页码 310-315出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2012.12.107
关键词
Electrochemical impedance; Electrochemical sensor; Interleukin-6; Gold nanoparticle; Single walled carbon nanotube array
资金
- NSFC [21073133, 51272182, 51025207]
- Zhejiang Provincial Natural Science Foundation of China [Y4080177, Y4090248, Y5100283]
- Zhejiang Scientific and Technological Innovation Fund [2011R424045]
A simple impedimetric immunosensor was developed for ultrasensitive detection of interleukin-6 (IL-6) antigen. The sensing platform integrated two substrates that had previously been employed individually to detect IL-6. This was constructed by electrochemically depositing Au nanoparticles on horizontally aligned single walled carbon nanotube array that has been in situ prepared on a SiO2/Si substrate. The as-prepared immunosensor was able to detect IL-6 antigen in serum at a low limit of 0.01 fgmL(-1), which was greatly lower than the detection limit reported with carbon nanotube forest or Au nanoparticles alone and was also significantly lower than that seen in a healthy individual. The sensor has a wide linear response range from 0.01 to 100 fgmL(-1) and also exhibits low responses to a number of interferents that were found in serum. The sensor has a high stability and its sensitivity does not change after being stored at 4 degrees C for a month. (c) 2013 Elsevier B.V. All rights reserved.
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