期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep15325
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资金
- JSPS through the Funding Program for Next Generation World-Leading Researchers (NEXT Program) [LR038]
- CSTP
- JSPS KAKENHI [26249127]
- Grants-in-Aid for Scientific Research [26630421, 26249127] Funding Source: KAKEN
Delivery of biomolecules with use of nanostructures has been previously reported. However, both efficient and high-throughput intracellular delivery has proved difficult to achieve. Here, we report a novel material and device for the delivery of biomacromolecules into live cells. We attribute the successful results to the unique features of the system, which include high-aspect-ratio, uniform nanoneedles laid across a 2D array, combined with an oscillatory feature, which together allow rapid, forcible and efficient insertion and protein release into thousands of cells simultaneously.
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