An effective turn-on rodamine-based fluorescent chemosensor for Cu (II) in living cells

An efficient turn-on rodamine-based fluorescent probe for intracellular Cu2+ image in living HeLa cells has been developed. The fluorescent probe exhibits high Cu2+ selectivity and excellent sensitivity (limit of detection is 1.2 x 10(-8) M) in CH3CN/HEPES (1/1, v/v) buffered solution and an immediate fluorescent response toward Cu2+ under physiological conditions. Moreover, the fluorescent probe effectuates the naked-eye detection of Cu2+. (C) 2013 Elsevier B. V. All rights reserved.