Gold nanorods-graphene oxide nanocomposite incorporated carbon nanotube paste modified glassy carbon electrode for voltammetric determination of indomethacin

A novel, simple and selective electrochemical method was investigated for the determination of indomethacin in aqueous media (phosphate buffer solution, pH 8.0) on gold nanorods-graphene oxide nanocomposite incorporated carbon nanotube paste modified glassy carbon electrode (GNRs-GO-CNTP/GCE) using square wave voltammetry (SWV). The GNRs-GO-CNTP/GCE displayed high effective surface area, more reactive sites and excellent electrochemical catalytic activity toward the oxidation of indomethacin. The detection limit of 1.7 x 10(-2) mu M and two linear calibration ranges of 0.2-0.9 and 2.5-91.5 mu M were obtained for indomethacin determination at GNRs-GO-CNTP/GCE. The proposed modified electrode was successfully applied for the determination of indomethacin in human blood serum, urine and pharmaceutical samples. (C) 2013 Elsevier B.V. All rights reserved.