期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 178, 期 -, 页码 648-655出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2013.01.011
关键词
Centrifugal microfluidics; Blood separation; Boycott effect; The Ponder-Nakamura-Kuroda theory
资金
- World Class University program [R32-2008-000-20054-0]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2012-0005090]
- Ministry of Education, Science and Technology
The plasma separation rate is enhanced significantly, as much as 8 times faster for whole blood, by simple change of the channel geometry in a rotating disc. It was enhanced in the channels with narrower channel widths and larger tilt angles with respect to the radial direction but independent of the channel depth or spin direction. A modified Ponder-Nakamura-Kuroda (PNK) theory could nicely fit all of the experimental data to a linear line, which data were obtained from spinning discs with various channel designs and blood samples with broad hematocrit range. To the best of our knowledge, this is the first investigation of geometry effects on the particle separation rate on a rotating disc and it will potentially contribute to the further performance enhancement of centrifugal microfluidic devices. (C) 2013 Elsevier B.V. All rights reserved.
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