期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 173, 期 -, 页码 329-337出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2012.07.023
关键词
RNA; Biosensors; Two-photon fluorescence; Bioimaging; Counterstain compatibility
资金
- National Science Foundation of China [50673053, 50173015, 30771091, 50990061, 50721002]
- NSFC/RGC [50218001, sklssm201207, 2011JC006]
- Hong Kong Research Grants Council of HKSAR [HKBU202709, HKUST2/CRF/10]
- Areas of Excellence Scheme, University Grants Committee of HKSAR [AoE/P-03/08]
- Hong Kong Baptist University [FRG2/10-11/101]
We have synthesized four indole derivatives (INS1, IND1, INS2 and IND2) successfully, and experimental results of biochemical RNA fluorescence assays and direct intracellular imaging demonstrated that they are potential highly RNA-selective fluorescent turn-on probes possessing good counterstain compatibility with the classic DNA-staining dye DAPI. Moreover, these sensors exhibit large two-photon excited fluorescence action absorption cross-section in the presence of RNA and are also capable of imaging intracellular RNA in two-photon fluorescence microscopy. (c) 2012 Elsevier B.V. All rights reserved.
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