期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 161, 期 1, 页码 1184-1190出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2011.11.025
关键词
Prothrombin time test; International normalized ratio; Microfluidic disc analyzer; Centrifugation; Mixing
资金
- National Science Council (NSC) [98-2221E-035-030]
- Feng Chia University
- Taichung Veterans General Hospital [TCVGH-FCU988205]
Prothrombin time test is used to measure the time required for blood to coagulate and is essential for monitoring appropriate drug dosing in patients taking oral anti-coagulants. To reduce the costs of reagents and improve the stability of tests, a microfluidic disc analyzer (MDA) has been developed. This analyzer can process small volumes of liquid samples (less than 10 mu l total volume required) and performs effective and fast mixing (within one second) under centrifugation. During the mixing process, two reactants can also maintain a constant ratio of flowrate. One hundred and one clinical samples were tested by the MDA and the Sysmex CA1500 coagulation analyzer, which was frequently used as a reference machine, for comparison. The test results from these two instruments show good correlation and agreement. (c) 2011 Elsevier B.V. All rights reserved.
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