期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 155, 期 2, 页码 837-842出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2011.01.058
关键词
Ordered mesoporous carbon; Isoniazid; Electrochemical sensor; Amperometric determination
资金
- National Natural Science Foundation of China [20875012]
In this work, an electrochemical sensor based on ordered mesoporous carbon (OMC) for the amperometric detection of isoniazid was developed. OMC was dispersed in a solution of Nafion, and the suspension was modified onto the surface of glassy carbon (GC) electrode. Cyclic voltammetry and amperometry were used to investigate the electrochemical behaviors of isoniazid on Nafion-OMC modified electrode (Nafion-OMC/GC). The results indicate that OMC can facilitate the electrochemical oxidation of isoniazid with a great decrease of overpotential in pH 7.0 phosphate buffer solution. The proposed biosensor provides excellent performance towards the determination of isoniazid with a high sensitivity of 0.031 mu A/mu M, a low detection limit of 8.4 x 10(-8) M and wide linear range from 1.0 x 10(-7) M to 3.7 x 10(-4) M at +0.20 V vs. Ag/AgCl. The method was successfully applied to the determination of isoniazid tablets with satisfying results. All the results suggest that Nafion-OMC/GC electrode is a potential candidate for a stable and efficient electrochemical sensor to detect isoniazid. (C) 2011 Elsevier B.V. All rights reserved.
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