期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 141, 期 1, 页码 187-191出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2009.05.035
关键词
Fluorescent chemosensor; Cu(II) ion; HGGG; Fluorescein
资金
- National Science Council (ROC)
- National Chiao Tung University
A new water-soluble fluorescent chemosensor Fluor-HGGG was synthesized by linking a tetrapeptide histidyl-glycyl-glycyl-glycine (HGGG) with fluorescein via standard solid-phase 9-fluorenylmethoxycarbonyl (Fmoc) chemistry. Significant fluorescence quenching was observed with Fluor-HGGG in the presence of Cu2+. Other metal ions including Ag+ Ca2+, Cd2+, Co2+, Fe2+, Fe3+, Hg2+, Mn2+, Ni2+ and Zn2+ produced only minor changes in fluorescence values for the system. The dissociation constant (K-D) of Cu2+ binding in Fluor-HGGG was found to be 37 mu M. The maximum fluorescence quenching caused by Cu2+ binding in Fluor-HGGG was observed over the pH range 7-7.5. (C) 2009 Elsevier B.V. All rights reserved.
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