期刊
SENSORS AND ACTUATORS A-PHYSICAL
卷 150, 期 2, 页码 280-285出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.sna.2008.12.021
关键词
Single-walled carbon nanotube (SWNT); Layer-by-layer (LbL) self-assembly; Immunosensor; MEMS
资金
- DARPA MEMS/NEMS Fundamental Research Program through the MF3 Center
A low-cost, flexible, and disposable immunosensor is presented in this paper. The single-walled carbon nanotubes (SWNTs) and biomolecules are self-assembled between two micro-patterned electrodes. The immuno-chip acts as a platform of a horseradish peroxidase (HRP) labeled sandwiched Enzyme-Linked ImmunoSorbent Assay (ELISA). The pH change induced by the biochemical reactions influences the electrical conductance of SWNT. A detection resolution of 0.4 ng/ml (2.5 pM) for normal rabbit immunoglobulin G (IgG) is demonstrated. The new fabrication technique and the HRP labeled detection protocol can be extended to the recognition of other antigens for critical applications to clinical diagnosis, food toxin detection, and environment monitoring. Published by Elsevier B.V.
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