期刊
SENSORS
卷 14, 期 5, 页码 8940-8949出版社
MDPI
DOI: 10.3390/s140508940
关键词
Chromobacterium violaceum CV026; N-hexanoyl-L-homoserine lactone (C6-HSL); N-octanoyl-L-homoserine lactone (C8-HSL); N-decanoyl-L-homoserine lactone (C10-HSL); N-dodecanoyl-L-homoserine lactone (C12-HSL); oral cavity; dentine caries; quorum sensing (QS)
资金
- University of Malaya, High Impact Research Grant, Ministry of Education, Malaysia (UM-MOHE HIR) [UM.C/625/1/HIR/MOHE/CHAN/14/1, H-50001-A000027]
Bacteria realize the ability to communicate by production of quorum sensing (QS) molecules called autoinducers, which regulate the physiological activities in their ecological niches. The oral cavity could be a potential area for the presence of QS bacteria. In this study, we report the isolation of a QS bacterial isolate C10B from dentine caries. Preliminary screening using Chromobacterium violaceum CV026 biosensor showed that isolate C10B was able to produce N-acylhomoserine lactones (AHLs). This bacterium was further identified as a member of Burkholderia, an opportunistic pathogen. The isolated Burkholderia sp. was confirmed to produce N-hexanoyl-L-homoserine lactone (C6-HSL), N-octanoyl-L-homoserine lactone (C8-HSL), N-decanoyl-L-homoserine lactone (C10-HSL) and N-dodecanoyl-L-homoserine lactone (C12-HSL).
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