期刊
SENSORS
卷 12, 期 3, 页码 2519-2538出版社
MDPI
DOI: 10.3390/s120302519
关键词
quorum sensing; biofilms; bacterial social interactions; bacterial infections
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN 311682-07]
- Canadian Institutes for Health Research (CIHR) [MOP-74487]
- Nova Scotia-CIHR
Many bacteria are known to regulate their cooperative activities and physiological processes through a mechanism called quorum sensing (QS), in which bacterial cells communicate with each other by releasing, sensing and responding to small diffusible signal molecules. The ability of bacteria to communicate and behave as a group for social interactions like a multi-cellular organism has provided significant benefits to bacteria in host colonization, formation of biofilms, defense against competitors, and adaptation to changing environments. Importantly, many QS-controlled activities have been involved in the virulence and pathogenic potential of bacteria. Therefore, understanding the molecular details of quorum sensing mechanisms and their controlled social activities may open a new avenue for controlling bacterial infections.
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