期刊
SENSORS
卷 12, 期 5, 页码 5940-5950出版社
MDPI AG
DOI: 10.3390/s120505940
关键词
fluorescent probe; glutathione; micelle-catalyzed; selectivity
资金
- National Institutes of Health [RO1 EB002044]
A fluorescent probe for glutathione (GSH) detection was developed. Our study indicates a possible mechanism which couples a conjugate addition and micelle-catalyzed large membered ring formation/elimination sequence. This method enables excellent selectivity towards GSH over other biological thiols such as cysteine (Cys) and homocysteine (Hcy). The proposed method is precise with a relative standard deviation (R.S.D) lower than 6% (n = 3) and has been successfully applied to determine GSH in human plasma with recoveries between 99.2% and 102.3%.
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