期刊
SENSORS
卷 11, 期 1, 页码 180-206出版社
MDPI
DOI: 10.3390/s110100180
关键词
bacterial luciferase; bioluminescent imaging; BLI; firefly luciferase; Lux; Luc
资金
- National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) [CBET-0853780]
- National Institutes of Health, National Cancer Institute [CA127745-01]
- Army Defense University
- NATIONAL CANCER INSTITUTE [R21CA127745] Funding Source: NIH RePORTER
In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern biological research. This process, which involves the noninvasive interrogation of living animals using light emitted from luciferase-expressing bioreporter cells, has been applied to study a wide range of biomolecular functions such as gene function, drug discovery and development, cellular trafficking, protein-protein interactions, and especially tumorigenesis, cancer treatment, and disease progression. This article will review the various bioreporter/biosensor integrations of BLI and discuss how BLI is being applied towards a new visual understanding of biological processes within the living organism.
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