期刊
SEMINARS IN THROMBOSIS AND HEMOSTASIS
卷 36, 期 8, 页码 857-864出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0030-1267039
关键词
Tissue factor; lipid rafts; microparticles; thrombosis; cancer
Evidence is emerging that tissue-factor-bearing microparticles and other microparticles arise from regions of the parent cell's plasma membrane that are rich in lipid rafts. In this brief review, we summarize the evidence for the raft origins of microparticles and the implications of these origins for the biological and medical consequences of microparticle production and for therapeutic strategies to diminish their production and potential to do harm.
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