期刊
SEMINARS IN THROMBOSIS AND HEMOSTASIS
卷 35, 期 8, 页码 723-734出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0029-1245105
关键词
Factor VIII inhibitors; risk factors; prophylaxis; genetic polymorphisms; factor VIII mutation; intensive treatment
资金
- ZLB Behring
- Novo Nordisk
- Wyeth
- Bayer
The most important complication in the treatment of hemophilia A patients today is the development of inhibitory antibodies against infused factor VIII (FVIII). Inhibitor development is caused by a complex interplay between both genetic and environmental factors. The risk of developing inhibitors is greatest in previously untreated patients with severe hemophilia A. Several genetic factors, such as a positive family history of inhibitors, ethnicity, FVIII genotype, and certain polymorphisms in immune modulatory genes, are associated with the risk of inhibitor development. Treatment-related factors, such as intensive treatment with FVIII for bleeds or surgery, are associated with a higher inhibitor risk. However, regular prophylaxis seems to have a protective effect on inhibitor development. Knowledge about the risk factors of inhibitor development is a condition for predicting and in the future possibly even preventing the development of inhibitors in patients with severe hemophilia A. This review summarizes the current knowledge on the potential risk factors of inhibitor development. At present, many uncertainties still remain that will require collaborative investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据