期刊
SEMINARS IN REPRODUCTIVE MEDICINE
卷 32, 期 1, 页码 35-42出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0033-1361821
关键词
microbiome; in vitro fertilization; Lactobacillus; progesterone
资金
- Intramural research program of the Program in Reproductive and Adult Endocrinology, NICHD, NIH
Although an altered vaginal microbiota has been demonstrated to affect parturition, its role in assisted reproductive technologies is uncertain. Nevertheless, the effect of known pathogens such as Mycoplasma tuberculosis, Chlamydia trachomatis, and Neisseria gonorrhoeae is clear, causing subclinical changes thought to be risk factors in subfertility. The Human Microbiome Project (HMP) has allowed for metagenomic studies to aid in characterizing normal vaginal flora. Recent findings from the HMP demonstrate that many different species of Lactobacillus are present in the vaginal tract, with a few that predominate. Studies that characterize the vaginal microbiome in assisted reproductive technology support the hypothesis that colonizing the transfer-catheter tip with Lactobacillus crispatus at the time of embryo transfer may increase the rates of implantation and live birth rate while decreasing the rate of infection. In addition, there is some evidence that a progesterone-resistant endometrium might increase the risk of an abnormal vaginal microbiome.
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