期刊
SEMINARS IN REPRODUCTIVE MEDICINE
卷 27, 期 3, 页码 207-217出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0029-1216274
关键词
Cytochrome P450 aromatase; CYP19; LH; sexual behavior; sexual partner preference; brain ischemia
资金
- NIH [RR14270, NS049210]
- American Heart Association [0535284N]
- NATIONAL CENTER FOR RESEARCH RESOURCES [R01RR014270] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS049210] Funding Source: NIH RePORTER
Aromatization of testosterone to estradiol by neural tissue has classically been associated with the regulation of sexual differentiation, gonadotropin secretion, and copulatory, behavior. However, new data indicate that the capacity for aromatization is not restricted to the endocrine brain and demonstrate roles for locally formed estrogens in neurogenesis and in responses of brain tissue to injury. This article summaries our current understanding of the distribution and regulation of aromatase in the brain and describes the classic and novel roles it plays. A better understanding of brain aromatization could shed new light on its physiologic and pathologic functions and someday lead to new, centrally acting drug therapies.
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