期刊
SEMINARS IN REPRODUCTIVE MEDICINE
卷 27, 期 5, 页码 351-357出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0029-1237423
关键词
Epigenetics; X-chromosome inactivation; imprinting; transgenerational inheritance
资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Institutes of Health, DHHS [1R03HD046553, 1R21RR021881, RO1HD045966]
- Reproductive Biology and Medicine Branch, NICHD
A vast array of successive epigenetic modifications ensures the creation of a healthy individual. Crucial epigenetic reprogramming events occur during germ cell development and early embryogenesis in mammals. As highlighted by the large offspring syndrome with in vitro conceived ovine and bovine animals, any disturbance during germ cell development or early ernbryogenesis has the potential to alter epigenetic reprogramming. Therefore the complete array of human assisted reproductive technology (ART), starting from ovarian hormonal stimulation to embryo uterine transfer, could have a profound impact on the epigenetic state of human in vitro produced individuals. Although some investigators have suggested an increased incidence of epigenetic abnormalities in in vitro conceived children, other researchers have refuted these allegations. To date, multiple reasons can be hypothesized why irrefutable epigenetic alterations as a result of ART have not been demonstrated yet.
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