期刊
SEMINARS IN REPRODUCTIVE MEDICINE
卷 27, 期 5, 页码 380-390出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0029-1237426
关键词
Environmental epigenetics; behavioral epigenetics; toxins and epigenetics; diet and epigenetics
资金
- NTH REACH IRACDA
- NTH [DP2120ODO01500-01]
- NIH NIDDK [R01DK080558-02]
- NICHD-Women's Reproductive Health Research (WRHR) Career Development Program [K12HD050128]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K12HD050128] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK080558] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [K12GM084897] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD001500] Funding Source: NIH RePORTER
Studies of environmental challenges, such as hazardous air pollutants, nonmutagenic toxins, diet choice, and maternal behavioral patterns, reveal changes in gene expression patterns, DNA methylation, and histone modifications that are in causal association with exogenous exposures. In this article we summarize some of the recent advances in the field of environmental epigenetics and highlight seminal studies that implicate in utero exposures as causative agents in altering not only the epigenome of the exposed gestation, but that of subsequent generations. Current studies of the effects of maternal behavior, exposure to environmental toxins, and exposure to maternal diet and an altered gestational milieu are summarized.
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