期刊
SEMINARS IN RADIATION ONCOLOGY
卷 20, 期 4, 页码 282-287出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semradonc.2010.05.006
关键词
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资金
- NCI NIH HHS [P01 CA129186] Funding Source: Medline
Genetic instability is one of the hallmarks of cancer cells. As tumors grow, they progressively acquire mutations that ultimately allow them to invade normal tissues and metastasize to distant sites. This increased propensity for mutation also leads to cancers that are resistant to therapeutic intervention. Recent evidence has shown that the tumor microenvironnnent plays a major role in the etiology of this phenomenon; as tumors are exposed to repeated cycles of hypoxia and reoxygenation, they downregulate a number of DNA repair pathways, thus leading to genetic instability. Understanding the mechanisms involved in this process may provide insights into the development of novel treatment strategies. Semin Radiat Oncol 20:282-287 (C) 2010 Elsevier Inc. All rights reserved.
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